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Release form, composition and packaging

Ingredients: sunflower oil (sunflower oil, antioxidants DL-alpha tocopherol and citric acid), lyophilized bifidobacteria (Bifidobacterium animalis subsp. lactis (BB-12), sucrose, maltodextrin, antioxidant sodium ascorbate).

Interaction with other drugs

Opaque capsules, white body, white cap.

The contents of the capsule are white, odorless powder.

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No clinically significant data on interactions with other drugs were found.

Linex® capsules can be prescribed simultaneously with antibiotics and chemotherapeutic agents.

When treating diarrhea, it is necessary to replace lost fluids and electrolytes.

No adverse interactions with other drugs were recorded. Taking Linex can be combined with the use of other drugs, including antibiotics and chemotherapy drugs.

Indications

— establishing and maintaining a balance in the composition and functional state of the intestinal microflora, incl. in children of the first year of life, with digestive disorders such as colic, gas formation, stool disorders (constipation, diarrhea) and other digestive disorders;

— maintaining the balance of the composition and functional state of the intestinal microflora when taking antibiotics and after completing a course of antibiotic treatment;

- reducing the risk of diarrhea caused by viral or bacterial infections of the gastrointestinal tract (including rotavirus infection);

— maintaining the formation and functioning of the immune system;

— prevention of atopic dermatitis in children.

Linex for children oral drops 8 ml bottle with dispenser

Compound

liquid for oral administration 8 ml in a bottle (with a dropper-dispenser, screw cap with a first opening ring), 1 bottle per package.
sunflower oil (sunflower oil, antioxidants DL-alpha tocopherol and citric acid), lyophilized bifidobacteria (Bifidobacterium animalis subsp. lactis (BB-12), sucrose, maltodextrin, antioxidant sodium ascorbate).

Pharmacokinetics

Bifidobacterium Bifidobacterium animalis subsp. lactis (BB-12) in the composition of “Linex for children drops” contributes to

&bull, establishing and maintaining a balance in the composition and functional state of the intestinal microflora, including in children of the first year of life with such digestive problems

Intestinal microflora disorders such as colic*, gas formation, stool disorders (constipation, diarrhea) and other digestive disorders,

&bull, maintaining the balance of the composition and functional state of the intestinal microflora when taking antibiotics and after completing a course of antibiotic treatment,

&bull, reducing the risk of diarrhea caused by viral or bacterial infections of the gastrointestinal tract (including rotavirus infection),

&bull, support in the formation and functioning of the immune system,

&bull, prevention of atopic dermatitis in children.

Factors that have a negative impact on the formation of the intestinal microflora of a newborn:

Children at risk for intestinal microflora imbalance:

&bull, caesarean section, premature birth,

&bull, unfavorable course of the neonatal period,

&bull, late breastfeeding,

&bull, long stay in a maternity hospital or hospital,

&bull, early artificial feeding,

&bull, physiological immaturity of intestinal motor function.

Unfavorable moments in a child’s life (risk of imbalance of intestinal microflora):

&bull, cessation of breastfeeding and/or introduction of complementary foods,

&bull, teething,

&bull, hospitalization,

&bull, stress (for example, separation from mother when she goes to work),

&bull, weaning, weaning from pacifiers,

&bull, treatment with antibacterial drugs (for example, antibiotics),

&bull, frequent acute respiratory infections,

&bull, intestinal infections,

&bull, unbalanced diet,

&bull, functional disorders of intestinal motility,

&bull, decreased immunity,

&bull, jet lag, long trips, change of residence.

These factors disrupt the natural colonization of the intestines with beneficial bacteria and can cause an imbalance of microflora (dysbiosis, dysbacteriosis), and therefore children at risk for imbalance of microflora are more prone to functional disorders of the gastrointestinal tract (GIT), food allergies, and are more susceptible to infections Gastrointestinal tract.

Indications for use

It is recommended as a biologically active food supplement for children from birth as a source of probiotic microorganisms - bifidobacteria (Bifidobacterium animalis subsp. lactis (BB-12)).

Linex probiotic drops for children contain important bifidobacteria for children: Bifidobacterium animalis subsp. lactis (BB-12).

Why were bifidobacteria chosen? Bifidobacterium animalis subsp. lactis (BB-12)?

Bifidobacteria are found in breast milk and begin to colonize the newborn's intestines from the first hours of life. Strain Bifidobacterium animalis subsp. lactis (BB-12) (strain DSM 15954) has high safety*, good tolerability and clinical efficacy in children from the neonatal period.

Bifidobacteria contribute to the natural formation of normal microflora and intestinal function, and also create an optimal environment in the intestines for the action of digestive enzymes. In addition, bifidobacteria ensure the correct formation of immunity and help reduce the risk of developing infectious diseases, the possibility of atopic dermatitis and food allergies in young children. In breastfed children, bifidobacteria make up 60-91% of the microflora.

* has GRAS status (Generally Regarded As Safe) in the FDA (GRAS Notice No. GRN 000049, 2002).

Contraindications

individual intolerance to dietary supplement components.

Directions for use and doses

Children from birth - 6 drops per day with meals. Drops can be added to milk, dairy or other non-hot drinks. Shake well before use.

Do not exceed the recommended daily dose.

When prescribed simultaneously with antibiotics, do not take

earlier than 3 hours after using antibiotics.

Take in consultation with your pediatrician.

Contents per daily serving (6 drops or 0.25 g): lyophilized bacteria Bifidobacterium animalis subsp. lactis (BB-12) - 1x10 9 CFU.

Duration of admission: 28 days. Repeated appointments are possible within a year.

Conditions for dispensing from pharmacies

Available without a prescription

Storage conditions

store in a dry place at a temperature not exceeding 25 o C, in the original packaging, out of the reach of children.

Once opened, store the bottle for no more than 28 days.

Best before date

2 years in unopened original packaging, 28 days in opened packaging.

Dosage regimen

The probiotic is taken orally with meals. Drops can be added to milk, dairy or other non-hot drinks. Shake well before use.

Children from birth are prescribed 6 drops/day with meals. Do not exceed the recommended daily dose.

Duration of treatment: 28 days. Repeated appointments are possible within a year.

Contents per daily serving (6 drops or 0.25 g): lyophilized bacteria Bifidobacterium animalis subsp. lactis (BB-12) - not less than 1x109 CFU.

Pharmacodynamics

Linex® normalizes intestinal microflora.

One capsule of Linex® contains at least 1.2 107 live lyophilized lactic acid bacteria: Lactobacillus acidophilus, Bifidobacterium infantis, Enterococcus faecium. Live lactic acid bacteria are a normal part of the natural intestinal microflora and are already present in the digestive tract of a newborn baby.

— fermentation of lactose shifts the pH factor to the acidic side. An acidic environment inhibits the growth of pathogenic and opportunistic bacteria and ensures optimal exposure to digestive enzymes;

- participate in the synthesis of vitamins B, K, ascorbic acid, thereby increasing the body’s resistance to adverse environmental factors;

- participate in the metabolism of bile pigments and bile acids;

— synthesize substances with antibacterial activity;

- increase the body's immune reactivity.

special instructions

The probiotic should be taken in consultation with your pediatrician.

When prescribed simultaneously with antibiotics, Linex for Children® drops should be taken no earlier than 3 hours after taking the antibiotics.

The nutritional value

pharmachologic effect

• Eubiotic [Medicines that normalize intestinal microflora]

Pharmacological effect - normalizing intestinal microflora.
Normalizes intestinal microflora. Maintains and regulates the physiological balance of intestinal microflora (microbiocenosis), ensures its physiological functions in the intestine.

Bacteria in Linex® restore the disturbed balance of intestinal microflora due to dysbacteriosis.

Live lactic acid lyophilized bacteria included in its composition are an integral part of the normal intestinal microflora, maintain and regulate the physiological balance of microbiocenosis in all parts of the intestine, have pronounced antagonistic properties against pathogenic and conditionally pathogenic flora, and participate in the synthesis of vitamins B1, B2, B6, B12 (in nature they are synthesized only by microorganisms), PP, K and E, folic and ascorbic acids, provide the body's need for biotin, and have immunostimulating properties.

By producing lactic acid and lowering the pH of the intestinal contents, the microorganisms used create favorable conditions for the absorption of iron, calcium, and vitamin D. Lactic acid bacteria carry out the enzymatic breakdown of proteins, fats and complex carbohydrates (including lactase deficiency in children) that are not absorbed into the body. in the small intestine, carbohydrates and proteins undergo deeper breakdown in the large intestine by anaerobes (incl.

bifidobacteria). The bacteria included in the drug facilitate the digestion of proteins in infants (bifidobacteria phosphoprotein phosphatase is involved in the metabolism of milk casein); participate in the metabolism of bile acids (formation of stercobilin, coprosterol, deoxycholic and lithocholic acids; promote the reabsorption of bile acids).

Taking into account the peculiarities of the distribution of microflora throughout the human gastrointestinal tract - the predominance of lactobacilli and lactic acid streptococcus in the small intestine, and bifidobacteria in the large intestine, Linex® ensures the supply of “medicinal” microflora in quantitatively and qualitatively balanced proportions.

The antagonistic properties of Linex® are associated with the ability of its constituent microorganisms to produce lactic and, to a lesser extent, acetic and propionic acids. The created acidic environment (the pH of the intestinal contents approaches 4.0-5.8) is unfavorable for the development of pathogenic and opportunistic microorganisms.

Self-medication may be harmful to your health. You should consult your doctor and also read the instructions before use.

Unfortunately, the treatment of many diseases requires the prescription of antibiotics.

As you know, antibiotics are very effective in treating many types of infections, but they destroy not only harmful, but also beneficial bacteria in the intestines. In order for the treatment to be effective but have fewer side effects, Linex is prescribed. When purchasing a drug at a pharmacy, pay attention to the expiration date.

Storage conditions and periods

The probiotic should be stored in its original packaging, out of reach of children, in a dry place at a temperature not exceeding 25°C. Shelf life: 2 years in unopened original packaging.

Linux is a good choice. The quality of goods, including Linex, undergo quality control by our suppliers. You can buy Linex on our website by clicking on the “Add to cart” button. We will be happy to deliver Linex to you at any address within our delivery zone indicated in the “Delivery” section, or you can order Linex for pickup.

Contraindications

The area of ​​use depends on the specific drug. Various medications from this line are used in therapeutic and pediatric practice to restore the intestinal microbiome. Prescription may occur if signs of disturbance in the number and composition of bacterial agents appear. The patient may complain of abnormal bowel movements, discomfort in the abdominal area, increased gas formation and other symptoms. It is recommended to first consult a gastroenterologist.

• Restoring and maintaining a healthy microbiome in a child from the first year of life, including patients suffering from intestinal colic and other unpleasant symptoms.
• Preventing the occurrence of infectious pathologies that cause the formation of loose stools.
• Restoring and maintaining a healthy microbiome during and after taking antibacterial medications.
• Normalization of the body's defense systems and prevention of the formation of atopic dermatitis.

• Drug therapy for microbiome disorders or prevention of this condition.
• Prevention of stool retention in patients over twelve years of age.
• Adjuvant therapy for Helicobacter pylori infection in patients over twelve years of age.
• Elimination of increased gas formation and other digestive disorders that appear during the use of antimicrobial agents, radiotherapy and other factors.

There are certain factors in the presence of which the medicine should not be used. These are conditions associated with immunity and other characteristics of the body. It is advisable to consult a specialist before therapy.

Main contraindications:

• Sensitivity to chemical compounds included in the dosage form and lactic acid products.
• Impaired absorption and assimilation of glucose or galactose.
• Inability to digest fructose.
• Deficiency of the enzymes lactase or isomaltase.

We suggest that you familiarize yourself with the time frame for the receipt of the insurance payment.
Individual intolerance to the components of dietary supplements.

It is recommended to consult a doctor before use.

Linex is recommended for use for the treatment and prevention of dysbacteriosis.

Symptoms of dysbiosis are: dyspepsia, diarrhea, vomiting, belching, constipation, nausea, flatulence, abdominal pain, and allergic skin reactions are also possible.

The use of Linex is contraindicated in case of hypersensitivity to any of its components or to dairy products.

Taking the drug during breastfeeding or pregnancy is considered safe.

Treatment and prevention of dysbacteriosis.

Dysbacteriosis is expressed by the following symptoms: diarrhea (diarrhea), dyspepsia (indigestion), constipation, flatulence (bloating), nausea, belching, vomiting, abdominal pain, allergic skin reactions are possible.

Hypersensitivity to drug components or dairy products.

Hypersensitivity to the components of the drug or dairy products.

Side effect

The drug is well tolerated. There are no reports of undesirable effects, but the possibility of hypersensitivity reactions cannot be excluded.

Undesirable effects when using lactic acid bacteria are extremely rare (occur in less than 1 case per 10,000 patients treated). An allergic reaction may occur.

If allergic reactions or undescribed side effects occur, you should stop taking Linex® and consult a doctor as soon as possible.

The medicine is considered safe and well tolerated. There are no documented adverse effects from the use of dosage forms. It is rare that the body may be sensitive to chemical compounds present in the powder, drops or capsules.

Another remedy

The drug is well tolerated, there is no information about undesirable effects, however, the possibility of developing hypersensitivity reactions should not be excluded.

Cases of overdose with Linex have not been reported at this time.