Why is water for injection needed?

Where is the expiration date indicated?

Not all places in the house are suitable for storing Paracetamol. It is not recommended to store the medicine:

• In the bathroom, because... increased humidity.
• In the immediate vicinity of heating devices, because the temperature regime is disrupted.
• In the kitchen cabinet in close proximity to the sink, stove and hood, because... In these places there is high humidity, there is a possibility of heating or contamination of the packaging.
• On the windowsill, because the drug is exposed to direct sunlight, this may cause the medicine to heat up.

The use of expired medications can lead to severe poisoning, dysfunction of the liver, kidneys and other serious pathological conditions.

The drug can be freely stored at home. A shelf in a closet, a refrigerator, or a special container with a lid is suitable for this. The home first aid kit should be located out of the reach of children. Even if a suspension has not been prepared from the powder, but the packaging has already been opened, such powder can be stored for no more than a month.

How to properly store medications

A medicine is a complex multicomponent system consisting of an active substance and excipients, including preservatives, dyes, sweeteners, and binding components. The safety of the pharmacological properties regulated by the manufacturer directly depends on compliance with certain conditions for each of the ingredients, and the drug itself as a whole. As a result, the effectiveness of the drug depends on several factors:

Temperature

Information on recommended temperature values ​​is contained in the instructions included with each drug. Even a slight temperature fluctuation can be detrimental to the components of the medication. For example, alcohol extracts and tinctures quickly become unusable at high temperatures, as the preservative that prevents the decomposition of substances is destroyed.

Sometimes a change in the state of the product can be noticed visually in the form of crystallization, cloudiness, or the appearance of flakes, in which case you can stop using it. But when chemical metamorphoses occur at the molecular level, that is, unnoticed by humans, this can lead to disastrous consequences.

Most solid and gaseous products packaged in aerosols are recommended to be stored at a temperature of 15-25 ˚C.

The inscription “in a cool place” means that the product must be placed in the refrigerator, since only there the temperature is maintained at up to 15 ° C. The recommendation “store at a temperature not exceeding 5 °C” should be interpreted as a requirement to put the medicine in the refrigerator.

These groups of drugs must be placed on different shelves:

• medicines in the form of candles are placed near the freezer;
• on the middle shelves of the refrigerator you can place tubes of ointments, gels and patches;
• For medications whose label indicates that they need to be stored in a cool place, you need to allocate space on shelves not adjacent to the freezer or on the refrigerator door, where a consistently cool temperature is maintained (10-15 ˚C).

To protect medications sent for storage in the refrigerator from moisture, it is recommended to additionally pack them in plastic bags or a hermetically sealed plastic storage container.

Medicines must not be frozen! After defrosting, irreversible chemical reactions occur in the active substance, the course of which even an experienced pharmacist cannot predict.

sunlight

All medicines are afraid of sunlight. Ultraviolet light is a catalyst for chemical and physical processes in medicines of various forms of release. It is impossible to recognize the “spoilage” of a medicine in time, so the medicines should be stored exclusively in a dark place (in a cabinet with a closing door) and away from heating appliances:

• syrups, tinctures, etc. are stored in the original cardboard packaging - this will provide “double protection” from light;
• It is recommended that tablets packaged in blisters should not be removed from the cardboard container, but stored in the same form as purchased at the pharmacy. As you use the medicine, you do not need to cut off the empty cells, since then the expiration date will be unknown.

Humidity

Most medications in the form of tablets, capsules, and powders are hygroscopic, that is, they easily absorb moisture, which changes their pharmacological properties. Therefore, you need to know where you can safely store your medications. It is not recommended to keep medications in the bathroom, even when placing medications in a special storage box, due to high humidity.

Air access

If the seal of the original packaging is broken, the active component of the drug may evaporate, oxidize, or interact with other chemicals. As a result, the effectiveness of the drug is reduced, and the effect of taking the medicine may be exactly the opposite of the expected result. Medicines should be stored in sealed containers and, after opening, used in accordance with the above standards.

Elderly people should not be allowed to squeeze out medicine purchased in a blister from its original cells, and then pour them into a common pile in an empty bottle. This storage method can lead to oxidation of the drug or a change in its properties due to contamination (tablets are taken with hands that contain bacteria).

Injection solutions that cannot be stored after destruction of the ampoule are used by many in this way: the medicine is kept in a syringe and used gradually, and the portion prescribed by the doctor is administered every day, and a cap is put on the syringe with the remaining drug. Although you can save a little on purchasing injections, you cannot store the product in a syringe for a long time.

It is not recommended to store medicine in a syringe

Possible consequences of using expired medicine

The lifespan of an opened bottle is significantly reduced. Opened syrup can be stored for 28 days. An opened bottle of powder for preparing a suspension, even with an unprepared suspension, can be stored for 1 month.

These rules apply subject to the rules for storing the drug and in the case when the original packaging in which paracetamol and products based on it are produced is not broken.

5 ml of suspension contains 120 mg of paracetamol. In one bottle the number of 5 ml doses is: 100 g - 16 doses, 150 g - 24 doses and 200 g - 32 doses.

The drug in the form of syrup and suspension can be bought today at any pharmacy. You don't even need a recipe for this. This also indicates the relative safety of the product.

Authorization

I was looking for PIRANTEL SUSPENSION: HOW LONG TO STORE AFTER OPENING

. FOUND! Storage. To store the drug Pyrantel in the form of a suspension, dry containers protected from sunlight are suitable. How long can the medicine be stored after opening?

Once opened, the drug is safe for a month. Storage. To store the drug Pyrantel in the form of a suspension, dry containers protected from sunlight are suitable. How long can the medicine be stored after opening?

Once opened, the drug is safe for a month. active ingredient: pyrantel; 5 ml of suspension contains pyrantel (in the form of pyrantel pamoate) - 250 mg. After opening the bottle, store with the cap tightly closed for 21 days. Storage. To store the drug Pyrantel in the form of a suspension, dry containers protected from sunlight are suitable. How long can the medicine be stored after opening?

Once opened, the drug is safe for a month. Pirantel suspension is an effective anthelmintic drug intended for children. For patients older than 6 months and up to the age of six, the suspension should also be given only after a doctor’s prescription and with. Pirantel suspension, instructions for use The suspension for children is used according to indications; it must be shaken before taking. Pyrantel suspension how long to store after opening - NO MORE PROBLEM!

Once the bottle has been opened, it can be stored for no more than 4 weeks. Pyrantel suspension is intended for oral (inside) use. It is taken orally in the morning after breakfast. The shelf life of Pirantel suspension is 3 years from the date of manufacture. The drug must be stored in. After opening, the tablets can be stored for three years, the suspension for 1 month. How long it takes for Pyrantel to act (tablets or suspension) depends on the rate of absorption in the body. After completion of treatment, it is necessary to conduct a control stool test for worm eggs. Storage conditions for the drug Pirantel. In a place protected from light, at a temperature of 15–25 °C. Keep out of the reach of children. Description of the drug Pirantel - instructions for use, indications and contraindications, release forms. After taking pyrantel, laxatives are not prescribed. Active ingredient: pyrantel; 5 ml of suspension contains pyrantel pamoate equivalent to 250 mg pyrantel. After first opening the bottle, store the drug for no more than 4 weeks. Pyrantel suspension and instructions suggest the following list of indications for its use. Pyrantel suspension how long to store after opening

- 100 PERCENT!

For the purpose of prevention, the doctor prescribes a single dose of the suspension either before a meal or immediately after it. Pyrantel suspension for children contains 250 mg of active substance in 5 ml. In what dose and for how many days should I use this medicine?

This is the most frequently asked question among parents. Pirantel. Dosage form. Oral suspension, 250 mg/5 ml. Storage conditions. Store at a temperature not exceeding 25°C. Protect from light. Shelf life after first opening the package is 21 days. How much does Pirantel anti-worm suspension for children cost?

. Elena, 49 years old: “We started giving the child Pirantel after tests showed the presence of pinworms in the intestines. Pirantel. suspension inside. After taking Pyrantel, laxatives are not prescribed. Keep out of the reach of children. Expiration date How do worms come out after Pirantel?

Dosage. The drug should be stored in a dry, dark place at an ambient temperature no higher than 25°C. If the bottle with the suspension is opened, the product can be used for a month. Pirantel suspension is one of the most effective and safe drugs for eliminating worms in both adults and children. The syrup contains a substance that paralyzes worms. After taking it, there is no need to give it. Pyrantel suspension is a homogeneous liquid with a pleasant taste, yellow in color. After taking a single dose, the maximum concentration of the active substance in plasma is achieved within 1-3 hours. Storage conditions and periods. The drug should be stored in a place protected from light and out of the reach of children. If we take Pirantel suspension for this, then how many days and in what dosage should it be taken in our case?

How long can Paracetamol for Children be stored after opening?

The same Otipax, which should be thrown away a month after use, is quite good for a year, as is Rinofluimucil. I think it’s the same song with this syrup, well, or at most it won’t work as it should, because... the effect of the active substance paracetamol has decreased or disappeared.

Turn the bottle upside down and gently pull the plunger down, drawing the suspension into the measuring syringe to the desired level. In adults, glucuronidation predominates, in newborns (including premature babies) and small children - sulfation. Conjugated metabolites of paracetamol (glucuronides, sulfates and conjugates with glutathione) have low pharmacological (including toxic) activity.

The suspension contains 2.4 grams of the active ingredient. As additional ingredients, it contains liquid sorbitol, strawberry flavor, purified water, methyl parahydroxybenzoate, xanthan gum, sucrose, glycerol.

When can the drug be stored for a long time?

Ceftriaxone in solution is prescribed not only for injection, it is also used to treat mucous membranes and skin in the following cases:

• irrigation of the oropharynx for ENT infections and gum diseases caused by bacterial microflora;
• treatment of skin or wounds when suppuration appears.

In these cases, it is impossible to use up the prepared solution immediately, so it is allowed to store Ceftriaxone in diluted form for 24 hours. A slight destruction of the active substances of the drug will not affect the effectiveness of the drug.

The shelf life of Ceftriaxone in diluted form for injection should not exceed 6 hours at room temperature and 12 in the refrigerator. The solution prepared for treating the skin or mucous membranes can be stored for a day and a change in color (becomes yellow-orange) does not indicate that the medicine has lost its effectiveness. But it should be remembered that Ceftriaxone has a maximum therapeutic effect within an hour, and then, during storage, the activity of the active substances decreases: it is recommended not to store the prepared solution for a long time, but to prepare it before use.

Found a mistake? Select it and press Ctrl + Enter

What happens during long-term storage?

The drug distributes evenly throughout all tissues, enters the brain structures, eliminating pain. How long does it take for Paracetamol syrup to work? The drug begins to eliminate unpleasant symptoms 15 minutes after its use. The duration of the effect depends on the individual characteristics of the body.

The drug is administered orally 1 to 2 hours after meals, washed down with plenty of liquid. Dosage frequency is 3-4 times with an interval of at least 4 hours.

Absorption is high, time to reach maximum concentration is 0.5-2 hours, maximum concentration is 5-20 mcg/ml.

According to the instructions for use, 5 ml of suspension contains 120 mg of the active substance - paracetamol. The product should be used orally, undiluted, after meals and with plenty of water. Shake the medicine well before use.

Penetrates the blood-brain barrier. Less than 2% of the dose of the drug taken by a nursing mother passes into breast milk. The therapeutically effective concentration of paracetamol in plasma is achieved when used at a dose of 10-15 mg/kg.

Paracetamol has several dosage forms:

• tablet,
• in the form of a suspension,
• syrup,
• powder,
• candles.

And storage of water for injections.

1. Why does healthcare need private practitioners?
2. And storage of purified water and water for injection
3. Dosage forms for injections. Requirements for them. Features of appointment and prescribing.
4. Aminocaproic acid solutions for injection.
5. Glycerin solutions for injection.
6. Sodium bicarbonate solutions for injection.
7. Solutions of nicotinic acid for injection.
8. SANITARY AND EPIDEMIOLOGICAL REQUIREMENTS FOR TRANSPORTATION, RECEIPT AND STORAGE OF FOOD RAW MATERIALS AND FOOD PRODUCTS
9. ST. PETERSBURG STATE PEDIATRIC MEDICAL ACADEMY OF THE FEDERAL AGENCY FOR HEALTH AND SOCIAL DEVELOPMENT (GOU VPO SPb SPMA ROSZDRAVA)

1. For the manufacture of solutions for injection, water for injection is used, which must pass the purified water test and must also be pyrogen-free.

2. The production of water for injection should be carried out in the premises of the distillation aseptic unit, where it is strictly prohibited to perform any work not related to the distillation of water.

3. Water for injection is used freshly prepared or stored at a temperature of 5 degrees. From up to 10 degrees. From or from 80 degrees. From up to 95 degrees. C in closed containers made of materials that do not change the properties of water, protecting it from mechanical inclusions and microbiological contaminants, for no more than 24 hours.

4. Water for injection is obtained using water distillers or other installations approved for this purpose.

5. When receiving water using an aqua distiller, it is necessary to wait for 10-15 minutes every day before starting work. carry out steaming with the water supply valves to the water distiller and refrigerator closed. The first portions of the resulting water within 15-20 minutes. drained. After this time, water collection begins.

6. The resulting water for injection is collected in clean, sterilized glass containers. Collections must have a clear inscription: “Water for injection.” If several collections are used simultaneously, they are numbered. The label of containers for collecting and storing water for injection must indicate that the contents are not sterilized.

7. Glass collections are tightly closed with stoppers with two holes: one for the tube through which water flows, the other for the glass tube into which a sterile cotton swab is inserted (changed daily). Collectors are installed on cylinder tippers.

8. The collectors are connected to the water distiller using glass tubes, silicone rubber hoses or other material indifferent to purified water, approved for use in medicine and resistant to steam treatment.

9. Water is supplied to workplaces through pipelines or in cylinders.

10. Tubes made of polymeric materials and glass can be sterilized with a 6% hydrogen peroxide solution for 6 hours, followed by thorough rinsing with purified water. Then they check for the absence of reducing substances. Pipeline processing is recorded in a special journal.

11. To remove pyrogenic substances, glass tubes and vessels are treated with an acidified solution of potassium permanganate for 25-30 minutes. To prepare the solution, add 6 parts of 1.5% sulfuric acid solution to 10 parts of a 1% solution of potassium permanganate. After treatment, the vessels and tubes are thoroughly washed with freshly prepared water for injection.

12. The head of the pharmacy appoints a person responsible for receiving purified water.

Appendix No. 7

Extract from the “Unified Rules for the Registration of Medicines Prepared in Pharmacies of Various Forms of Ownership” (guidelines) 1997.

Date added: 2015-10-11 | Views: 545 | Copyright infringement

Previous33Next

Nosological classification (ICD-10)

The opened bottle can be stored with the cap screwed on at room temperature under normal conditions, or in the refrigerator. This will not affect the shelf life. What conditions is Paracetamol “afraid of”? The shelf life of suppositories and suspensions is 2 years, and storage conditions are almost the same as for paracetamol tablets.

We always take Erespal for coughs, it can be stored open until it expires, and there is also our analogue Inspiron, so it can only be stored for 30 days after opening... BUT!

Further in the article we will talk about Paracetamol syrup for children. From the instructions it is known that it has a viscous consistency, a gray or yellow tint and a strawberry aroma.

Paracetamol is a medicine used primarily to reduce fever. And also to relieve symptoms, for example, relieve headaches.

Can it be stored diluted?

The peculiarities of Ceftriaxone and other antibacterial drugs of the cephalosporin and penicillin series are such that before administering the drugs, they must be mixed with physiological sodium chloride solution or an anesthetic.

After dilution of the drug, the following occurs:

• When interacting with the solution, the active components in the powder transform into an active form;
• Maximum activity lasts for about an hour, and then the active substances in the solution begin to disintegrate into inactive elements.

At room temperature, after only 6 hours of storing the diluted powder, the effectiveness of the solution is reduced by almost half.

Sometimes patients who are undergoing treatment at home are interested in whether the drug will retain its effectiveness if it is stored diluted in the refrigerator with a frequency of Ceftriaxone injections twice a day.

Indeed, lowering the temperature slows down the disintegration of the active substances, but injections are given at intervals of 12 hours and if stored for a long time, Ceftriaxone will still reduce its effectiveness. If the doctor prescribes Ceftriaxone injections twice a day, then this should be done, diluting the next portion of the drug immediately before administration.

Instructions for use Paracetamol suspension for children

The expiration date is indicated on the bottle itself; the suspension is stored for a maximum of 3 years; an open bottle of medicine is stored for the same amount of time. does not deteriorate if you follow storage rules. When used together with barbiturates, tricyclic antidepressants, alcohol, anticonvulsants (phenytoin), phenylbutazone, rifampicin, the risk of developing the hepatotoxic effect of paracetamol significantly increases.

Orally, adults - 200–500 mg 2–3 times a day; children 6-12 months - 25-50 mg 2-3 times a day, up to 5 years - 100-150 mg, up to 12 years - 150-250 mg 2-3 times a day.

The therapeutic properties of the drug lie in its effect on thermoregulation centers and pain centers, resulting in an increase in the threshold of sensitivity to pain. The drug has high absorption and reaches its maximum concentration in plasma after two hours.

Is it possible to store injection medicine?

Is it possible to store injection medicine? ¶

From: Elena M. - January 28, 2006 0:33

I don't think I found this kind of information anywhere on the forum. The question is that the pig was given injections (ketonal, dexamethasone), but the dose, of course, is very small. Is it possible to take the remains from the ampoule, for example, into a syringe and put it in the refrigerator? If so, how many days can everything be stored like this (a day, two)? And is it possible to use one syringe at least twice? Or should everything be thrown away - including the ampoule with a bunch of medicine and the syringe? The instructions for the medications don't say anything. Thanks in advance for your advice.

Is it possible to store injection medicine? ¶

From: Nikita - January 28, 2006 1:43

I’m currently injecting Ketonal and Dexamethasone. Both the pharmacy and the doctor assured me that it was impossible to store the opened ampoule. Every time I open a new one. And I use new syringes; the pharmacy did not recommend it for the second time (with a non-removable needle).

Interesting: How Long Does Urine And Blood Test Work?

Is it possible to store injection medicine? ¶

From: Hiruda - January 28, 2006 1:54 am

Syringes definitely cannot be used a second time. But in the clinic where I was practicing, the remaining medicine was drawn into a sterile syringe, i.e. out of the package and stored in the refrigerator for about 3-4 days. And the owners were allowed to do so. None of the patients complained and the effect of the treatment was the same as that of treatment with drugs from the new ampoules.

Is it possible to store injection medicine? ¶

From: dillemma - January 28, 2006 3:08 am

The ampoule definitely cannot be stored open. It is correct to do everything disposable. Of course, it is drawn into a sterile syringe, in theory it can be in the refrigerator, but I would not, since there are syringes of different quality. Hiruda, there is a difference in how they work in practice and what the basic rules are. In practice, they are sometimes abused. P.s. I am a former medical worker.

Is it possible to store injection medicine? ¶

From: Nikita - January 28, 2006 4:23

Hiruda?, were these particular drugs used? In my opinion, giving advice on storage is a big responsibility, especially the strange period of 3-4 days, so 3 or 4? and what is the temperature in the refrigerator? And I also wanted to ask, I was just interested, “none of the patients complained,” if the patient is a rodent, is it really possible to recognize what he is complaining about. Please tell us how, well, if he is, for example, a guinea pig (this is a simple case, it still makes a lot of different sounds), or if it is a rabbit (a complex case, there are few sounds).

Is it possible to store injection medicine? ¶

From: Lelsi - January 28, 2006 12:16 pm

I bought the Katozal veterinary hospital, in a syringe, 5 cc. for 5 days, the doctor said that it can be stored in the refrigerator.

Is it possible to store injection medicine? ¶

From: Elena M. - January 28, 2006 14:19

As for the syringe, Alshinetsky said that you can use one syringe twice, but then the needle simply becomes dull. But syringes are not as expensive as medicines. Regarding the leftovers. We are not talking about an ampoule, but about storage in a syringe. The refrigerator has a special compartment for storing medicines (a closed drawer in the door). I called White Fang, they also advised me to put it into a syringe and into the refrigerator. I think that, of course, it won’t last a week, but two days is enough. Similar advice was given at the pharmacy, where the seller injected Ketonal into the dog and also kept the leftovers in the refrigerator. After all, for example, ketonal should be injected into pork twice a day. Is it really impossible to keep the medicine in the syringe at least until the evening? It’s just that maybe pig breeders themselves have their own experience on this issue?

I don't think I found this kind of information anywhere on the forum. The question is that the pig was given injections (ketonal, dexamethasone), but the dose, of course, is very small. Is it possible to take the remains from the ampoule, for example, into a syringe and put it in the refrigerator? If so, how many days can everything be stored like this (a day, two)? And is it possible to use one syringe at least twice? Or should everything be thrown away - including the ampoule with a bunch of medicine and the syringe? The instructions for the medications don't say anything. Thanks in advance for your advice.

Paracetamol for children can be ordered with delivery or booked in pharmacies:

If you follow the method of using children's paracetamol in suspension according to the instructions, the drug rarely causes side effects and is well tolerated by the body. But in some cases, using the product is contraindicated. Such contraindications include the following conditions:

• Hypersensitivity to components;
• Kidney or liver failure;
• In complex treatment along with other medications that contain a similar active substance;
• Lack of glucose in the blood;
• Pathologies of the organs of the hematopoietic system;
• Children under three months of age.

The top line displays the batch of the medicinal product, and below, in the “best before” column, the expiration date is displayed. On currency packaging (paper matrix), the series and expiration date are marked on the back side.

The separation of this ring from the lid confirms the fact that the package has been opened with all the ensuing consequences.

An overdose of paracetamol can cause liver failure, which may lead to the need for a liver transplant or death. In addition, acute pancreatitis is observed, accompanied by liver dysfunction and hepatotoxicity.

Does paracetamol have an expiration date and how should it be stored correctly?

If you need to extend the course of treatment longer than recommended, be sure to consult your doctor!

After opening the package, it is better to put the syrup and suspension on the refrigerator door. The temperature there is slightly higher than in the main chamber. The same conditions are suitable for suppositories whose storage temperature is +8°C - +15°C.

Paracetamol syrup for children and Paracetamol suspension are forms of the drug created specifically for the youngest patients. The liquid viscous consistency is very convenient for babies to take.

The medicine should be kept in a cool place, away from sunlight. This requires moderate air humidity.

Can I use expired?

Attention: sometimes people forget to check whether the medicine is still valid and take it; you should not immediately panic, especially if the medicine is only a few days or weeks out of date. Of course, it should be thrown away immediately, since if you regularly take a drug whose period of action has expired, then in addition to the appearance of side effects, the general condition of the patient worsens.

Paracetamol, just like any other drug, should be used only for a strictly permitted period of time, in this way negative effects on the human body can be avoided. It should also be remembered that if there are small children in the house, the product should be stored out of their reach.

Using expired or unsuitable medicine can cause serious harm to health. The risk of developing allergic reactions increases significantly. An allergy to Paracetamol manifests itself in the form of skin manifestations, rash, itching, Quincke's edema or anaphylactic shock.

Important! Bottles of syrup and suspension have a first-opening control ring. The separated ring from the screw cap is a fact confirming the opening of the drug.

Storage conditions and expiration dates

Details about the dosage and features of taking Paracetamol in the form of syrup and suspension can be read in the attached instructions for use (instructions for syrup and suspension). It describes dosages depending on age. But a more significant point is the patient’s weight.

The same period of time is the guaranteed shelf life of the drug, provided there is no damage to the manufacturer’s packaging. If symptoms of overdose occur, immediately stop taking the drug and consult a doctor.